Cancer is emerging as a global problem that is likely to become the dominant health care issue in the world - and one that Singapore is uniquely positioned to address. The Cancer Research Centre of Excellence (RCE), directed by Professor Daniel Tenen, has developed a highly interactive and diverse group of investigators that spans the gamut from bench to bedside research. One of its primary aims is to recruit world class investigators to revolutionise its research capability and work towards becoming one of the top cancer research centres in the world.