SAIC-Frederick, Inc., a subsidiary of SAIC, is the Operations and Technical Support (OTS) Contractor for the National Cancer Institute at Frederick (NCI-Frederick) a federally funded research and development center. The mission of SAIC-Frederick, Inc. is to provide scientific, technical, management, administrative, and logistical support to National Institutes of Health (NIH) intramural laboratory research and development related to the causes of and cures for cancer and AIDS. Intramural research is that conducted by Government scientists operating within various units of NIH, principally the National Cancer Institute (NCI), and the largest institute of NIH. We also conduct basic and applied research in cancer and AIDS; operate and manage the Advanced Biomedical Computing Center (ABCC), the world's only supercomputer devoted exclusively to biomedical research; and conduct large drug and natural product screening programs.

SAIC-Frederick, Inc., is one of four related NCI contracts on-site and serves as the infrastructure support for the entire center. The contract is the largest single research contract awarded by the Department of Health and Human Services (DHHS) and it is the department's only Government-owned, contractor-operated facility contract.