The National Center for Computational Toxicology (NCCT) is a part of EPA's Office of Research and Development (ORD). Located in Research Triangle Park, North Carolina.  NCCT coordinates and implements EPA's research in the field of computational toxicology. The NCCT provides scientific leadership, understanding and tools related to the application of mathematical and computer models to technologies derived from computational chemistry, molecular biology and systems biology in order to improve the Agency's data reporting requirements, priority setting approaches to understanding chemical toxicity, and risk assessment approaches.  The major challenge of the research program is to improve the predictive capabilities of the methods, models and measurements that constitute the input materials to the computational models.