The Case Western Reserve University School of Medicine is the largest biomedical research institution in Ohio and ranked 15th among the nation's medical schools for research funding from the National Institutes of Health. A primary goal of the School is to conduct cutting-edge biomedical research that leads to improvement in clinical care and the development of new knowledge in the biomedical sciences. Emphasis is placed on programs that promote interdisciplinary research and innovation. Top research themes at the School of Medicine include: cancer; cardiovascular health and disease; infection and inflammation, metabolism and disease and neuroscience. Other research strengths include biomedical engineering, imaging and translational research. The Case Comprehensive Cancer Center is the only NIH-designated comprehensive cancer center in Ohio and is affiliated with both the University Hospitals Case Medical Center and the Cleveland Clinic. Other facilities of note include the Case Center for Imaging Research and Center for Proteomics and Bioinformatics. Case Western Reserve University is located in Cleveland, Ohio. Cleveland is a culturally diverse city located on the shore of Lake Erie, one of the Great Lakes. Recreational, cultural and educational opportunities abound, including a world-class orchestra (The Cleveland Orchestra) and art museum (The Cleveland Museum of Art), one of the largest performing arts centers in the US (Playhouse Square), and four new sports (MLB, NFL, NBA and college basketball) facilities downtown.