PICSL is a dynamic and growing group led by Profs. James C. Gee and Paul A. Yushkevich. The group is involved in many exciting biomedical imaging projects, including development of novel analysis methodologies; application of the state-of-the-art techniques to clinical studies; and translational research. PICSL is deeply committed to the principles of open science, and is a leader in development and dissemination of open-source image analysis applications (ITK-SNAP, ANTS, DTI-TK). PICSL is a part of the graduate groups of the Departments of Computer and Information Science, and Bioengineering. It is affiliated with the Centers for Functional Neuroimaging, for Bioinformatics and for Cognitive Neuroscience, the Institutes for Medicine and Engineering and for Translational Medicine and Therapeutics, the General Robotics, Automation, Sensing and Perception Laboratory, the Working Group on Applied Mathematics and Computational Science, and the Leonard Davis Institute of Health Economics, and is a founding member of the Center for Health Informatics at Penn, the Penn Center for Musculoskeletal Disorders, and the National Library of Medicine Insight Consortium.