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| Location: | Nantes, France |
| Description: |
The main research objective of the "Nuclear Oncology Research" team is the development of targeted radionuclide therapy, and more specifically of radioimmunotherapy, to treat disseminated cancers.
1. Improving radionuclide targeting techniques by the use of innovative radionuclides in relationship with the implantation of the Arronax cyclotron in Nantes, of pretargeting strategies and of colloidal vectors. 2. Using high LET radionuclides, very toxic at short range, such as alpha emitters. 3. Developing multimodality treatments that synergize with radioimmunotherapy 4. Searching for new target antigens, expressed by tumor cells or their environment 5. Controlling the efficacy and toxicity of targeted radionuclide therapy by quantifying precisely (quantitative imaging) the absorbed doses delivered to tumor cells and normal tissues (dosimetry) and by understanding the biological effects of ionizing radiations (radiobiology). 6. Transferring the results to the clinics in radioimmunotherapy (RIT), molecular imaging and PET quantification and intraoperative tumor detection.
Group 1: Radionuclide targeting in oncology (leaders: Alain Faivre-Chauvet and Jean-François Gestin) Group 2: Experimental and clinical nuclear oncology (leaders: Michel Chérel, François Davodeau and Françoise Kraeber-Bodéré) Group 3: Dosimetry of targeted radionuclide therapy (leader: Manuel Bardiès)
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| Website: | http://www.inserm.fr |
| Dept Site: | http://www.crcna.univ-nantes.fr/63132923/0/fiche___pagelibre/&RH=1228735028697 |
| Sector: | Academia |
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