A postdoctoral fellowship position is available for a candidate with training in molecular biology and genetics to perform pQTL and eQTL investigations of susceptibility to neonatal lung disease in inbred mice. This project is part of a NIEHS Director’s Challenge Program that utilizes a multi-disciplinary approach to understand mechanisms of oxidant stress-induced disease. The mouse positional cloning project will interface closely with a prospective epidemiological investigation of the genetic basis of susceptibility to bronchopulmonary dysplasia. The long range goal of the translational project is to identify and functionally characterize genetic polymorphisms in murine candidate genes and determine whether they associate with chronic lung disease in high-risk neonates.

The ideal candidates will have a Ph.D., M.D., or equivalent degree in genetics, molecular biology, cell biology, or a related field. Experience with positional cloning approaches, mouse models, and gene expression profile analysis would be helpful. Additional knowledge of biostatistics is desirable.

While candidates with up to two or fewer years of relevant postdoctoral research experience are eligible, recent graduates are encouraged to apply.

Key Words: genetic susceptibility; oxidants; oxidative stress; lung injury; inflammation; bronchopulmonary dysplasia; positional cloning; infant; chronic lung disease; environmental lung disease

TO APPLY: Click on the button below, or submit a cover letter, curriculum vitae, bibliography, and the names of three references by e-mail to Dr. Steven R. Kleeberger (kleeber1@niehs.nih.gov).

The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina.


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The National Institute of Environmental Health Sciences (NIEHS), located in Research Triangle Park, North Carolina, is one of 27 research institutes and centers that comprise the National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS). The mission of the NIEHS is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.

The NIEHS traces its roots to 1966, when the U.S. Surgeon General announced the establishment of the Division of Environmental Health Sciences within the NIH. In 1969, the division was elevated to full NIH institute status. Since then, the NIEHS has evolved to its present status as a world leader in environmental health sciences, with an impressive record of important scientific accomplishments and a proud history of institutional achievements and growth under the leadership of former directors Paul Kotin, M.D. (1969–1971), David P. Rall, M.D., Ph.D. (1971–1990), and Kenneth Olden, Ph.D. (1991–2005).

Today, under the guidance of its 2006–2011 Strategic Plan, the NIEHS is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere.