The DOE Joint Genome Institute (JGI) in Walnut Creek, CA has an exciting Postdoctoral research opportunity available in the Structural Genomics Program. Will create, design, and execute experiments to study the assembly and structural basis function of carboxysomes and related bacterial microcompartments. Research will be conducted at the DOE Joint Genome Institute with access to the University of California, and the Lawrence Berkeley Laboratory, and offers a rich and dynamic scholarly environment with the latest in genomics, bioinformatics and structural biology research. Position reports to the Structural Genomics Program Lead.

Specific Job Duties

Essential -
- Create, design, execute and interpret structure-based experiments to explore the structural basis of microcompartment function and measure phenotypic change on microcompartment assembly and function in bacteria.
- Biochemical and biophysical characterization of proteins.
- Design and carry out experiments (from protein preparation to structure analysis) aimed at elucidating the structural basis of bacterial microcompartment function.
- Evaluate and implement appropriate tools for structural studies.
- Troubleshoot all stages of experimental process from protein preparation through structure analysis.
- Attend and present technical status reports at group meetings and keep an accurate and detailed laboratory notebook.
- Supervise and train undergraduates, graduate students, technical staff and other group members as necessary

Marginal -
- Conduct X-ray crystallographic structure determination, SAXS and structure analysis of component proteins of bacterial microcompartments
- Attend and present technical status reports at group meetings.


Key Success Factors

Essential -
- PhD in biochemistry, biophysics, or a closely related field.
- Demonstrated experience in recombinant molecular biology (site-directed mutagenesis, proteins overexpression and purification).
- Training in current molecular genetic techniques, including site-directed mutagenesis ideally in cyanobacteria.
- Ability to work independently and as a team member in a diverse team environment.
- Working Knowledge of bioinformatics tools.
- Effective interpersonal skills necessary for working in a diverse team environment.
- Working knowledge of Bioinformatics tools.

Marginal -
- Knowledge of imaging techniques and biophysical characterization of proteins.
- Experience in all phases of X-ray structure determination (including data processing, phase determination and improvement, model building, and protein structure refinement).

To apply:

How To Apply

To apply from this page, click the link below to be redirected to the lab posting then follow the on-line instructions to complete the application process. As part of the online application process, please submit a single attachment that includes both your resume or CV and a cover letter. Please be sure to reference where you found out about the position.

http://jobs.lbl.gov/LBNLCareers/details.asp?jid=22176&p=1

Lawrence Berkeley National Laboratory (Berkeley Lab) has been a leader in science and engineering research for more than 70 years. Located on a 200 acre site in the hills above the University of California's Berkeley campus, adjacent to the San Francisco Bay, Berkeley Lab holds the distinction of being the oldest of the U.S. Department of Energy's National Laboratories. The Lab is managed by the University of California, operating with an annual budget of more than $500 million (FY2004) and a staff of about 3,800 employees, including more than 500 students.

Berkeley Lab conducts unclassified research across a wide range of scientific disciplines with key efforts in fundamental studies of the universe; quantitative biology; nanoscience; new energy systems and environmental solutions; and the use of integrated computing as a tool for discovery. It is organized into 17 scientific divisions and hosts four DOE national user facilities.