Nuclear receptors play an important role in the regulation of embryonic development and many other physiological functions and have been implicated in many human diseases. Our lab studies the physiological functions of the retinoic acid-related orphan receptors (RORs), which function as transcription factors. In addition, we investigate several aspects of the ROR signaling pathway. and the role of RORs in disease, including obesity, cancer, and inflammatory disease. The role of RORs in osteogenesis, adipose tissues, circadian rhythm, metabolism, and in the immune system are being investigated using ROR-knockout mice. Putative target genes are being identified by microarray analysis using these target tissues.

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Dr. Anton Jetten
NIEHS, NIH
Research Triangle Park, NC 27709 U.S.A.
Telephone: (919) 541-2768
E-mail: jetten@niehs.nih.gov

You may send inquiries to the same address.

The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina.

Publications

• Nakajima, T., Fujino, S., Nakanishi, G., Kim, Y-S., and Jetten, A.M.. TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4. Nucl. Acids Res. 32:4194-4204 (2004).
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• Jetten, A.M. Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs). Current Drug Targets-Inflammation & Allergy. 3:393-410 (2004).
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• Kang, H-S., Beak, J.Y., Kim, Y-S., and Jetten, A.M. NABP1, a novel RORγ-regulated gene encoding a single-stranded nucleic acid binding protein. Biochem. J. 397:89-99 (2006)
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• Jetten, A.M., and Joo, J.H. Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development. Adv. Develop. Biol. 16:314-354 (2006)
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• Jaradat, M., Stapleton, C., Tilley, S., Dixon, D., McCaskill, J.M., Kang, H.S., Angers, M, Liao, G., Jetten, A.M. Modulatory role for retinoid-related orphan receptor α (RORα) in allergen-induced lung inflammation. Am. J. Resp. Crit. Care Med. 174:1299-1309 (2006).
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• Tilley, S., Jaradat, M., Stapleton, C., Dixon, D., Kim, S-C., Erikson, C.J., McCaskill, J.M., Liao, G., Koller, B.H., and Jetten, A.M. Reduced Susceptibility to Allergen-induced Airway Inflammation in Mice Deficient in Retinoid-related Orphan Receptor (ROR) γ. J. Immunol. 178:3208-3218 (2007).
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• Nurieva, R., Yang, X.O., Panopoulos, A.D., Martinez, G., Zhang, Y., Ma, L., Schluns, K., Tian, Q., Watowich, S., Jetten, A.M., and Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448:480-483 (2007).
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• Kang, H.S., Angers, M., Beak, J.Y., Wu, X., Gimble, J.M., Wada, T, Xie, W., and Jetten, A.M. Gene expression profiling reveals a regulatory role for RORα and RORγ in Phase I and Phase II Metabolism. Physiol. Genomics (31:281-294 (2007).
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• Wada, T., Kang, H.S., Angers, M., Gong, H., Batia, S., Khadem, S., Ren, S., Ellis, E., Strom, S.C., Jetten, A.M., and Xie, W. Identification of oxysterol 7α-hydroxylase (Cyp7b1) as a novel RORα target gene and a functional crosstalk between RORα and LXR. Mol. Pharm. 73: 891-899 (2008)
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• Yan, J., Yang, X-P., Kim, Y-S., and Jetten, A.M. RAP80 responds to DNA damage induced by both IR and UV irradiation and is phosphorylated at Ser205 in vivo. Cancer Res. 68: 4269-4276 (2008)
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• Joo, J.H. and Jetten, A.M. NF-κB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. J. Biol. Chem. 283:16391-16399 (2008)
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• Yang, X.O., Nurieva, R., Martinez, G.J., Kang, H.S., Chung, Y., Pappu, B.P., Shah, B., Chang, S.H., Schluns, K.S., Watowich, S.S., Feng, X.H., Jetten, A.M., and Dong, C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29:44-56 (2008)

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The National Institute of Environmental Health Sciences (NIEHS), located in Research Triangle Park, North Carolina, is one of 27 research institutes and centers that comprise the National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS). The mission of the NIEHS is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.

The NIEHS traces its roots to 1966, when the U.S. Surgeon General announced the establishment of the Division of Environmental Health Sciences within the NIH. In 1969, the division was elevated to full NIH institute status. Since then, the NIEHS has evolved to its present status as a world leader in environmental health sciences, with an impressive record of important scientific accomplishments and a proud history of institutional achievements and growth under the leadership of former directors Paul Kotin, M.D. (1969–1971), David P. Rall, M.D., Ph.D. (1971–1990), and Kenneth Olden, Ph.D. (1991–2005).

Today, under the guidance of its 2006–2011 Strategic Plan, the NIEHS is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere.