Glis proteins are Kruppel-like zinc finger transcription factors that are closely related to Gli proteins. Glis proteins exhibit multiple functions. They play a critical role in pancreatic development and several renal diseases. Mice deficient in Glis3 develop diabetes and polycystic kidneys. Glis3 is critical in the development of endocrine functions, including beta cells. Mutations in Glis3 have been linked to a neonatal syndrone with diabetes and hypothyroidism, renal disease, and cancer. Our lab is interested in understanding various aspects of the Glis3 signaling pathway, the role of the primary cilium and the role of Glis in the regulation of gene transcription. Moreover, we study the functions of Glis in pancreatic development and polycystic kidney disease, and cancer.

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Dr. Anton Jetten
NIEHS, NIH
Research Triangle Park, NC 27709 U.S.A.
Telephone: (919) 541-2768
E-mail: jetten@niehs.nih.gov

You may send inquiries to the same address.

The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina.

Publications

• Zhang, F., Nakanishi, G., Kurebayashi, S., Yoshino, K., Perantoni, A., Kim, Y-S., and Jetten A.M. Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor expressed predominantly in kidney. Identification of transactivation and repressor functions. J. Biol. Chem. 277: 10139-10149 (2002).
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• Kim, Y-S., Lewandoski, M., Perantoni, A., Kurebayashi, S., and Jetten, A.M. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. J. Biol. Chem. 277: 30901-30913 (2002).
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• Kim, Y-S., Nakanishi, Gen, Lewandoski, M., and Jetten, A.M. GLIS3, a novel member of the GLIS subfamily of Krüppel-like Zinc Finger Proteins with Repressor and Activation Functions. Nucl. Acids Res. 31: 5513-5525 (2003).
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• Kim, S-C., Kim, Y-S., and Jetten, A.M. Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1). Nucl. Acids Res. 33:6805-6815 (2005).
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• Kim, Y-S., Kang, H.S., and Jetten, A.M. The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/β-catenin signaling pathway. FEBS Letters. 581:858-864 (2007)
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• Beak, J.Y., Kang, H.S., Kim, Y-S., and Jetten, A.M. Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. J. Bone Mineral Res. 22:1234-1244 (2007).
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• Beak, J.Y., Kang, H.S., Kim, Y-S., Jetten, A.M. Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1). Nucl. Acids Res. 36: 1690-1702 (2008)
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• Kim, Y-S., Kang, H.S., Herbert, R., Beak, J.Y., Collins, J.B., Grissom, S.F., and Jetten, A.M. Deficient Krüppel-like zinc finger protein Glis2 expression in mice results in progressive chronic kidney disease and renal failure. Mol. Cell. Biol. 28: 2358-2369 (2008).

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