Two Postdoctoral positions are available to study the pathogenesis of Helicobacter pylori (Hp) using mouse infection and cell line models. Inoculated mice develop several pathogenic changes associated with H. pylori infected humans. Our knowledge of the mechanism of H. pylori pathogenesis is incomplete. The projects include the use of a mouse and tissue models to study H. pylori infection, detection methods, host responses pathogenic mechanism(s), an in vivo expression technology to identify genes induced during infection as well as vaccine development. The in vivo expression studies of Hp will involve molecular biology and microarray techniques.

Highly motivated candidates with a background in molecular biology microarray analyses, immunology (Flow cytometry), and an interest in bacterial pathogenesis are encouraged to apply. Please click on the button below, or send curriculum vitae and the names of three references to:

William G. Coleman
Laboratory of Genetic and Biochemistry
NIDDK, NIH
Building 8, Room 2A02
8 Center Drive MSC 0830
Bethesda, MD 20892

NIH is an equal opportunity employer.

Contact Information: William G. Coleman, Jr., Ph.D., Group Leader, Section on Laboratory Biochemical Pharmacology, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive Diseases, Bldg 8/2A-02, 8 Center DR MSC 0830, Bethesda, MD 20892, Fax: (301) 402-0240, Telephone: (301) 496-9108, E-mail: wc3z@nih.gov.


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The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) conducts and supports research on many of the most serious diseases affecting public health. The institute supports much of the clinical research on the diseases of internal medicine and related subspecialty fields as well as many basic science disciplines.

The Institute's Division of Intramural Research encompasses the broad spectrum of metabolic diseases such as: diabetes, obesity, inborn errors of metabolism, endocrine disorders, mineral metabolism, digestive and liver diseases, nutrition, urology and renal disease, and hematology. Basic research studies include: biochemistry, biophysics, nutrition, pathology, histochemistry, bioorganic chemistry, physical chemistry, chemical and molecular biology, and pharmacology.

NIDDK extramural research is organized into four divisions: Diabetes, Endocrinology and Metabolic Diseases; Digestive Diseases and Nutrition; Kidney, Urologic and Hematologic Diseases; and Extramural Activities.

The Institute supports basic and clinical research through investigator-initiated grants, program project and center grants, and career development and training awards. The Institute also supports research and development projects and large-scale clinical trials through contracts.