Postdoctoral research positions are available to study the molecular mechanisms that lead to hematologic malignancy. Our laboratory uses non-random chromosomal translocation breakpoints associated with human leukemia as a point of entry for these studies. We have used genes identified at translocation breakpoints to model T-cell acute lymphoblastic leukemia (SCL, LMO1; EMBO J. 16:2408-19, MCB 19:5025-35, Blood 107:2540-3), AML (CALM-AF10 fusions), and myelodysplastic syndrome (NUP98-HOX fusions; Blood 106:287-95, Cancer Res 67:5148-55). Ongoing studies are using these models 1) to identify collaborative events associated with leukemic transformation, 2) to identify and characterize cancer stem cells, and 3) to determine the utility of these animal models for pre-clinical evaluation of drug efficacy. We are particularly interested now in complementary studies that are focused on identifying and characterizing the mechanisms that lead to non-random chromosomal translocations (Hum Mol Genet 10:2481-91, DNA Repair 4:1038-46). Our laboratory uses a combination of molecular genetics, animal models, cell culture, and high-throughput genomics to address these questions.

The National Institutes of Health (NIH) intramural program provides an exciting and stimulating training environment. Candidates must have a Ph.D. and/or M.D and less than 5 years postdoctoral training. To apply for a position, please click on the button below, or send a CV and names of three references to:

Peter D. Aplan, M.D.
Senior Investigator
Genetics Branch, NCI, NIH
NNMC Building 8, Room 5101
8901 Wisconsin Avenue
Bethesda, MD 20889
E-mail: aplanp@mail.nih.gov

For additional information about our research program, visit our Web site, http://ccr.cancer.gov/Staff/staff.asp?profileid=5671.

This position is subject to a background investigation.


The NIH is dedicated to building a diverse community in its training and employment programs.

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The National Cancer Institute coordinates the National Cancer Program, which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Specifically, the Institute:

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