The National Heart, Lung and Blood Institute, a major component of the NIH and the DHHS, is recruiting for a Postdoctoral Fellow within the Molecular Biology Section of the Translational Medicine Branch. The successful candidate would join a group of investigators examining the molecular and cellular biology of mitochondrial regulation in the development of cardiovascular diseases and diabetes. Applicants should have a Ph.D. and/or an M.D. with experience in advanced molecular and cellular biology. Prior studies involving proteomics, identification of protein:protein interactions, expertise in viral vector work, and experience with transgenic mice would be advantageous.

The focus of the research is to augment our understanding how the mitochondrion is regulated at the molecular level to modulate cardiac and skeletal muscle function in diabetes. Retrograde signaling from the mitochondria to nucleus as a component in this regulation is also being explored. The research work will integrate genetic, proteomic, and biochemical approaches in animal disease models and/or in cell culture.


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The National Heart, Lung, and Blood Institute (NHLBI) provides leadership for a national program in diseases of the heart, blood vessels, lung, and blood; blood resources; and sleep disorders. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.

The Institute plans, conducts, fosters, and supports an integrated and coordinated program of basic research, clinical investigations and trials, observational studies, and demonstration and education projects. Research is related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The NHLBI plans and directs research in development and evaluation of interventions and devices related to prevention, treatment, and rehabilitation of patients suffering from such diseases and disorders. It also supports research on clinical use of blood and all aspects of the management of blood resources. Research is conducted in the Institute's own laboratories and by scientific institutions and individuals supported by research grants and contracts.

For health professionals and the public, the NHLBI conducts educational activities, including development and dissemination of materials in the above areas, with an emphasis on prevention.

The NHLBI supports research training and career development of new and established researchers in fundamental sciences and clinical disciplines to enable them to conduct basic and clinical research related to heart, blood vessel, lung, and blood diseases; sleep disorders; and blood resources through individual and institutional research training awards and career development awards.

The Institute coordinates relevant activities in the above areas, including the related causes of stroke, with other research institutes and federal health programs. Relationships are maintained with institutions and professional associations, and with international, national, state, and local officials as well as voluntary agencies and organizations working in the above areas.