Research in the Meistrich laboratory focusing on regulation of differentiation of spermatogonial stem cells. 

The goal of the research is to elucidate the molecular and cellular mechanisms underlying our discovery that treatment of rats with radiation, chemotherapy drugs, or some environmental toxicants induces a complete block in spermatogonial differentiation, but that this block is reversed by suppressing testosterone.  This provides a direct approach to studying the role of hormonally regulated paracrine factors produced by somatic cells on spermatogonial differentiation. 

The techniques used to investigate these questions include molecular studies of the endocrine regulation of gene expression in vivo and in isolated androgen-responsive somatic cell subpopulations and in tissue culture where we can also assess the progression of differentiation, spermatogonial stem cell and somatic cell transplantation to restore damaged function, and modeling these effects in genetically engineered rodents.  Candidates with experience in mammalian reproductive biology and molecular biology will be considered. 

To apply:

Send CV and list of 3 references to Dr. Marvin L. Meistrich, meistrich@mdanderson.org, Mailing address: Dept. Experimental Radiation Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Blvd. Houston, TX. 77030

Univ. Texas M. D. Anderson Cancer Center is an equal opportunity/affirmative action employer.

The University of Texas M. D. Anderson Cancer Center is located with other institutions on the Texas Medical Center campus.  M. D. Anderson Cancer Center has excellent resources and core facilities and is an exciting intellectual environment with many opportunities for collaboration and learning.