Seeking a highly qualified postdoctoral fellow with experience in molecular biology, biochemistry, chromatin or knock-out/transgenic mice to study the role of H1 linker histones and chromatin remodeling ATPases in development and gene regulation. We have prepared a unique series of knock-out mice and cell lines lacking H1 histones and the ISWI-type SNF2H chromatin remodeling factor.  Our studies have revealed a role for H1 histones and SNF2H in blood cell development, DNA damage repair and apoptosis, and gene regulation, including DNA methylation and imprinting.

Nishiyama, M., et al. (2009).  CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol 11:172-82.

Giambra, V.,  et al. (2008).  Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus. Mol Cell Biol 28, 6123-33.

Murga, M., et al. (2007).  Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol 178:1101-8.

Chong, S., et al. (2007).  Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 39:614-22.

Fan,Y., et al. (2005).  Depletion of histone H1 in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell 123:1199-212.

Konishi, A., et al. (2003).  Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell 114:673-88.

Stopka, T. and A. I. Skoultchi. (2003).  The ISWI ATPase Snf2h is required for early mouse development. Proc Natl Acad Sci U S A 100:14097-102.

To apply: Please send or fax a C.V. and 3 letters of reference to:

 Dr. Arthur I. Skoultchi

Professor and Chair

Department of Cell Biology

Albert Einstein College of Medicine

1300 Morris Park Avenue

New York, New York 10461

skoultch@aecom.yu.edu

FAX:  (718) 430-8574

EOE