A Postdoctoral Fellowship is available at the Laboratory of Molecular Pharmacology, National Cancer Institute under the supervision of Dr. Mirit I. Aladjem. Our studies focus on molecular signaling pathways that determine when and where DNA replication starts on chromatin. These issues are essential for the understanding of cancer growth because accurate replication is vital for genomic stability and variations in cell cycle signaling pathways contribute to the wide range of sensitivity of various cancers to anti-cancer drugs. In recent studies, we have identified a replicator element within the human beta globin locus that dictates replication sites and timing and have characterized epigenetic factors that contributed to the establishment of replication timing. We have also shown that replicators can alter chromatin condensation in their vicinity. We currently focus on DNA-protein interactions of replicators and replication timers. The successful applicant will engage in studies focusing on how cell cycle regulators interact with replicators to alter the accessibility and condensation status of chromatin at different stages of cell growth and in response to anti-cancer agents.

For additional information, visit our Web sites: http://ccr.cancer.gov/staff/staff.asp?profileid=5813 and http://www3.cancer.gov/intra/lmp/MABIO.HTM.

Enthusiastic individuals who seek to join our group are encouraged to submit an application by clicking on the button below. Alternatively, applicants can send an e-mail message to Dr. Aladjem expressing their interest and including their CV, list of publications and names and contact information of 3 individuals who can serve as professional references.

This position is subject to a background investigation.


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The National Cancer Institute coordinates the National Cancer Program, which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Specifically, the Institute:

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• Conducts research in its own laboratories and clinics.
• Supports education and training in fundamental sciences and clinical disciplines for participation in basic and clinical research programs and treatment programs relating to cancer through career awards, training grants, and fellowships.
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• Collaborates with voluntary organizations and other national and foreign institutions engaged in cancer research and training activities.
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• Supports construction of laboratories, clinics, and related facilities necessary for cancer research through the award of construction grants.