Background in molecular biology, expertise with murine models, and experience in management of a mouse colony are strongly preferred. Applicants must have a Ph.D. or M.D. and less than 5 years of postdoctoral experience. Candidates should click on the button below or send a copy of their CV, bibliography, and contact details including phone number and e-mail address for at least 2 references to: Joan C. Marini, M.D., Ph.D., Chief, BEMB, NICHD, NIH, by e-mail to oidoc@helix.nih.gov.

The Bone and Extracellular Matrix Branch of NICHD conducts translational research on genetic disorders of bone. Our interest is in understanding the biochemical and molecular mechanisms by which defects in components of matrix cause bone disease, and then in applying this information for the care of our pediatric patients. We are seeking to fill a postdoctoral position employing murine models of genetic bone disease. The fellow will use the murine model previously generated in our lab, the Brtl knock-in mouse for osteogenesis imperfecta, as well as lead the generation of novel transgenic and knock-in mice. Project topics include:

1. Investigation of mechanism of bone quality improvement by homozygosity for a dominant collagen mutation;
2. Gene therapy of osteogenesis imperfecta by suppression of mutant mRNA. The lab has developed a transgenic mouse expressing a ribozymes, which is specific to the Brtl mutation. This project involves development of gene therapy with ribozymes and RNA at in vitro, tissue culture, and murine levels and includes development of expression constructs and assessment of in vivo co-localization and efficacy;
3. Investigation of bone level mechanism of Brtl bone dysplasia and its modulation by puberty.

To apply:

The NICHD was initially established to investigate the broad aspects of human development as a means of understanding developmental disabilities, including mental retardation, and the events that occur during pregnancy. Today, the Institute conducts and supports research on all stages of human development, from preconception to adulthood, to better understand the health of children, adults, families, and communities.