Our goal is to understand how HIV-1 replicates and how its interactions with the host cell influence its replication. We are active in three major research areas. First, we are defining the structure and function of host restriction factor APOBEC3G and 3F proteins. Specific research projects include the mechanisms by which APOBEC proteins inhibit HIV-1 replication, structural determinants of interaction between HIV-1 Vif protein and APOBEC proteins, mechanisms of APOBEC protein incorporation into virions, biochemical characterization of APOBEC proteins, and their in vivo regulation. Second, we are elucidating mechanisms by which HIV-1 reverse transcriptase (RT) acquires resistance to RT inhibitors. Our specific research aims are to further define the role of the C-terminal connection and RNase H domains of RT in antiviral drug resistance in subtype B as well as non-B subtypes of HIV-1. Third, we are exploring the in vivo mechanisms of reverse transcription by using a novel quantitative strand-specific amplification technology that we recently developed. Further details and a list of relevant publications can be found at http://home.ncifcrf.gov/hivdrp/Pathak.html.

Postdoctoral positions are currently available to participate in these studies. Interested candidates should have a Ph.D. with a strong background in molecular virology and/or molecular biology and biochemistry. To apply, candidates should click on the button below or send a cover letter, CV including bibliography, and contact information for three references to the following address:

To apply:

The National Cancer Institute coordinates the National Cancer Program, which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Specifically, the Institute:

• Supports and coordinates research projects conducted by universities, hospitals, research foundations, and businesses throughout this country and abroad through research grants and cooperative agreements.
• Conducts research in its own laboratories and clinics.
• Supports education and training in fundamental sciences and clinical disciplines for participation in basic and clinical research programs and treatment programs relating to cancer through career awards, training grants, and fellowships.
• Supports research projects in cancer control.
• Supports a national network of cancer centers.
• Collaborates with voluntary organizations and other national and foreign institutions engaged in cancer research and training activities.
• Encourages and coordinates cancer research by industrial concerns where such concerns evidence a particular capability for programmatic research.
• Collects and disseminates information on cancer.
• Supports construction of laboratories, clinics, and related facilities necessary for cancer research through the award of construction grants.