A postdoctoral fellow position is open in the Antibody and Protein Purification Unit (APPU) at the National Cancer Institute in Bethesda, MD. We are a core unit that provides antibody design and purification services to NCI principal investigators and their staff. The APPU helps with the isolation of proteins and characterization of their post-translational modifications by mass spectroscopy. As an analytical protein facility, we design electro-chemiluminescence based assays for proteins. Current projects include the development of monoclonal antibodies to the Prolactin receptor, S100a7, and SpanxN and their use for development of Electro-chemiluminescence based ELISA assays for applications related to cancer detection and prognosis. We have developed antibodies to cancer stem cells and a major commitment of resources of our unit will be used to identify the putative cancer stem cell antigens recognized by the antibodies.

The successful candidate will pursue a specific project within one or more of these areas of translational and basic research, to be defined according to the experience and attributes of the individual.

Applicants should possess a Ph.D., M.D., or equivalent degree in chemistry or biochemistry and have some experience with protein purification and western blotting. Candidate must have excellent verbal and written communication skills as well as organizational skills. Appointment duration is up to 5 years. Stipends are commensurate with education and experience. The position is available immediately.

This position is subject to a background investigation.

Interested individuals should click on the button below or submit a cover letter, curriculum vitae, bibliography, and a list of 3 references to:

Dr. Paul K. Goldsmith
Head, Antibody and Protein Purification Unit
NCI/CCR/OD/OSTP
37 Convent Drive
Building 37, Room 6134
Bethesda, MD 20892
E-mail: paulg@mail.nih.gov

The NIH is an Equal Opportunity Employer. Applications from women, minorities, and persons with disabilities are strongly encouraged. The NCI/NIH is a smoke-free environment.


The NIH is dedicated to building a diverse community in its training and employment programs.

To apply:

The National Cancer Institute coordinates the National Cancer Program, which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Specifically, the Institute:

• Supports and coordinates research projects conducted by universities, hospitals, research foundations, and businesses throughout this country and abroad through research grants and cooperative agreements.
• Conducts research in its own laboratories and clinics.
• Supports education and training in fundamental sciences and clinical disciplines for participation in basic and clinical research programs and treatment programs relating to cancer through career awards, training grants, and fellowships.
• Supports research projects in cancer control.
• Supports a national network of cancer centers.
• Collaborates with voluntary organizations and other national and foreign institutions engaged in cancer research and training activities.
• Encourages and coordinates cancer research by industrial concerns where such concerns evidence a particular capability for programmatic research.
• Collects and disseminates information on cancer.
• Supports construction of laboratories, clinics, and related facilities necessary for cancer research through the award of construction grants.