A position for a PhD thesis entitled "Molecular Mechanism of Ribonucleoproteins" is available starting January 2009. This study will address the function of ribonucleoproteins catalyzing pseudouridine formation during the early stages of ribosome biogenesis. The PhD project will include reconstitution of active ribonucleoproteins from purified proteins and RNAs for mechanistic studies. In particular, rapid kinetic and fluorescence techniques will be applied to identify critical steps during RNA modification.

The applicant needs a M.Sc. degree (or comparable) in biochemistry or biology and must be fluent in English. Experience in biochemical techniques such as protein purification and/or molecular biology such as molecular cloning and site-directed mutagenesis is required. Additional experience in biophysical techniques such as enzyme kinetics or fluorescence is an asset.

For more information see: www.uleth.ca/~ute.kothe.

To apply:

The following documents should be electronically submitted to ute.kothe@uleth.ca by September 12th 2008:

1. Cover Letter explaining your Motivation
2. Detailed CV
3. Most recent transcript
4. Two Reference Letter
5. Evidence of English Language Proficiency (if second language)